Table 3 G4-interacting proteins in humans
From: In vivo dynamics and regulation of DNA G-quadruplex structures in mammals
Name | Binding | Function | Intracellular role | Refs. |
|---|---|---|---|---|
BLM | DNA eG4s | 3'–5' unfolding | DNA helicase Involved in DNA replication, DNA repair, and recombination | [52] |
WRN | DNA eG4s | 3'–5' unfolding | DNA helicase Involved in DNA replication, DNA repair, and recombination | [50] |
DHX36 | DNA and RNA eG4s | 3'–5' unfolding | DNA helicase and RNA helicase Involved in maintaining genome stability and regulating transcription and translation | [55] |
DHX9 | DNA and RNA eG4s | 3'–5' unfolding | DNA helicase and RNA helicase Involved in maintaining genome stability and regulating transcription and translation | [54] |
Pif1 | DNA eG4s | 5'–3' unfolding | DNA helicase Involved in maintaining genome stability and telomere maintenance | [57] |
FANCJ | DNA eG4s | 5'–3' unfolding | DNA helicase Involved in maintaining genome stability | [58] |
DNA2 | DNA eG4s | 5'–3' unfolding | DNA helicase Involved in the replication of telomeric DNA | [59] |
ChlR1 | DNA eG4s | 5'–3' unfolding | DNA helicase Involved in sister chromatid cohesion, DNA replication, and recombination | [60] |
CNBP | DNA and RNA eG4s | Unfolding | CCHC-type zinc finger nucleic acid binding protein, transcription factor Involved in regulation of transcription and translation | [62] |
POT1 | DNA eG4s | Unfolding | Telomere protection protein Involved in telomere protection and extension | [64] |
MAZ | DNA eG4s | Unfolding | Zinc-finger transcription factor Involved in transcription regulation | [63] |
XPD | DNA eG4s | Unfolding | Helicase subunit of the general transcription factor TFIIH Involved in transcription initiation and DNA damage repair | [61] |
Nucleolin | DNA eG4s | Stablization | Nucleolar protein, transcription factor Involved in transcription regulation | [65] |
LARK | DNA and RNA eG4s | Stablization | CCHC-type zinc finger-containing protein, transcription factor Involved in regulation of transcription and translation | [66] |
APE1 | DNA eG4s | Stablization | Apurinic/apyrimidinic (AP) endonuclease Involved in DNA damage repair and transcription regulation | [67] |