Fig. 5
From: In vivo dynamics and regulation of DNA G-quadruplex structures in mammals
Regulation of eG4 dynamics and cancer treatment. Cancer cells grow and divide indefinitely in vivo, leading to tumor growth and disease progression. There are two potential ways to target G4 in cancer treatment. The first method is to use G4-stabilizing ligands to prevent the unfolding of the proto-oncogene promoter eG4s, thereby reducing the expression of proto-oncogenes in cancer cells (yellow). The second method is to kill cancer cells by combining DSBs caused by G4-stabilizing ligands with inhibition of the HR or NHEJ pathway (magenta)