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Fig. 3 | Cell & Bioscience

Fig. 3

From: Extracellular matrix remodelling and stiffening contributes to tumorigenesis of salivary carcinoma ex pleomorphic adenoma——A study based on patient-derived organoids

Fig. 3

PA and CXPA organoids exhibited accurate recapitulations of genetic alterations of their parental tumours. (a) Mutation spectrum analysis of primary tumour (left column) and organoids (right column) of PA. (b) Mutation spectrum analysis of parental tumour (left column) organoids (right column) of CXPA. (c) Characteristics of 96 trinucleotide mutations in PA organoids and parental tumour. (d) Characteristics of 96 trinucleotide mutations in CXPA organoids and parental tumour. The most common mutation types in (c) and (d) are shown in a black frame. e-h. The Circos plot is divided into five layers from outside to inside, illustrating the chromosome bands (the chromosome number and chromosome-scale), sequencing coverage, indel distribution (the value is the number of indel within 500 kb bases), SNP distribution (the number of SNP within 500 kb bases) and CNV distribution (the number of CNV within 500 kb bases. (e) Parental tumour of PA, (f) PA organoids, (g) Parental tumour of CXPA, and (h) CXPA organoids

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Cell & Bioscience

ISSN: 2045-3701

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