Fig. 2
From: Advances in the allostery of angiotensin II type 1 receptor
Allosteric modulators and pockets of AT1R. A AT110il and CLR are allosteric modulators of AT1R. B The active and inactive states of AT1R shows significant structural change in the binding site of AT1R-AAs. C A cryptic allosteric pocket is formed during MD simulation. D1) S1I8-bound AT1R with allosteric compound DCP1 and AT1R-AAs binding epitope are highlighted. D2) The cartoon picture of D1). E1) A potential cryptic allosteric pocket P6 is observed by using Fpocket. P6 is only identified during the movement of H8. E2) The cartoon picture of E1).