Fig. 1
From: Advances in the allostery of angiotensin II type 1 receptor
The protein structure of human AT1R. Secondary structure of human AT1R with depiction of different motifs and important sites. Cys18–Cys274, the disulfide bond, stabilizes the N terminus and ECL3. And Cys101–Cys180 stabilizes TM3 and ECL2. The DRY motif and NPxxY motif, the microswitches of AT1R, are considered to participate in receptor activation. The interaction, N1113.35 hydrogen bonds with N2957.46, stabilizes the inactive state of AT1R.