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Fig. 3 | Cell & Bioscience

Fig. 3

From: FFAR2 antagonizes TLR2- and TLR3-induced lung cancer progression via the inhibition of AMPK-TAK1 signaling axis for the activation of NF-κB

Fig. 3

Gene sets related to cytokines and chemokines were enriched in FFAR2DownTLR2UpTLR3Up LTTs vs. FFAR2UpTLR2DownTLR3Down LTTs. A-J. GSEA (http://www.gsea-msigdb.org/gsea/index.jsp) was performed for Group A (FFAR2DownTLR2UpTLR3Up LTTs) vs. Group B (FFAR2UpTLR2DownTLR3Down LTTs). Ten gene sets related to cytokines and chemokines were significantly enriched in FFAR2DownTLR2UpTLR3Up LTTs vs. FFAR2UpTLR2DownTLR3Down LTTs (A and B. cytokine receptor activity and binding; C and D. TNF superfamily cytokine production; E and F. positive regulation of IL-6 production; G. IL-1 pathway; H and I. IL8-CXCR1 and IL8 CXCR2 pathway; J. CXCR4 pathway). NES and the nominal p-value are indicated in each inner panel

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Cell & Bioscience

ISSN: 2045-3701

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