Fig. 2

Gene sets related to innate signals were enriched in FFAR2^DownTLR2^UpTLR3^Up LTTs vs. FFAR2^UpTLR2^DownTLR3^Down LTTs. A-J. GSEA (http://www.gsea-msigdb.org/gsea/index.jsp) was performed for Group A (FFAR2^DownTLR2^UpTLR3^Up LTTs) vs. Group B (FFAR2^UpTLR2^DownTLR3^Down LTTs). Ten gene sets related to innate signals were significantly enriched in FFAR2^DownTLR2^UpTLR3^Up LTTs vs. FFAR2^UpTLR2^DownTLR3^Down LTTs (A. toll-like receptor signaling pathway; B. TLR1/2 cascade; C. toll endogenous pathway; D. TLR signaling related to MyD88; E and F. NOD and NLR signaling pathways; G. inflammasomes; H. NF-κB pathway; I. NF-κB canonical pathway; J. NLRP3 in inflammasome). NES and the nominal p-value are indicated in each inner panel