Fig. 1
The association between FFARs and TLRs in lung cancer. A. FFAR2 was significantly down-regulated in LUAD and LUSC. FFAR2 expression was compared between tumor and normal tissues by gene expression profiling interactive analysis (GEPIA, http://gepia.cancer-pku.cn/detail.php?gene=FFAR2) data. *P < 0.05. B and C. FFAR2 expression was negatively correlated with TLR2 and TLR3 expression in LUAD (B, TLR2, p-value = 0.026, R = -0.1; C, TLR3, p-value = 0.039, R = -0.094). D. The different magnitudes of FFAR2 (∆FFAR2), TLR2 (∆TLR2), and TLR3 (∆TLR3) were analyzed in NSCLCs (n = 42, LTT vs. matched LNT). E-P. Based on ∆FFAR2, ∆TLR2, and ∆TLR3, six LTTs were selected (Group A, three LTTs with FFAR2DownTLR2UpTLR3Up, indicated by green boxes in D; Group B, three LTTs with FFAR2UpTLR2DownTLR3Down, indicated by red boxes in D). GSEA (http://www.gsea-msigdb.org/gsea/index.jsp) was performed for Group A vs. Group B. Twelve gene sets for cancer modules were significantly enriched in Group A vs. Group B. NES and the nominal p-value are indicated in each inner panel