Fig. 2
Ligand binding modes in human PRPS2 filament. A Hexamer of human PRPS2 filament. Each chain is marked with a different color. The areas marked in red are those shown in Figures B, C and D. B ADP is recognized on the allosteric site and active site of human PRPS2 filament, while R5P binding site is bound by Pi. The residues interacting with ligands are indicated. Residues in chain b are numbered with the ‘ symbol, and the residues in chain c are numbered with the “ symbol. C Ligands of the active site of human PRPS2 filament. ADP and Mg2+ occupy ATP binding sites at active sites. Pi can also be seen in the active site. Each chain is marked different colors. D ADP in the allosteric site of human PRPS2 filament. Each chain is marked with different colors