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Fig. 3 | Cell & Bioscience

Fig. 3

From: Liver-specific in vivo base editing of Angptl3 via AAV delivery efficiently lowers blood lipid levels in mice

Fig. 3

Base editing outcomes of Angptl3 in the liver tissues of the mice. (A, B) Quantification of editing efficiency at the genomic DNA (A) and the transcript (B) levels by BEAT analysis of Sanger sequencing data. AAV9-Anc, AAV9-hAAT-Anc/Angptl3 treated group. ****p < 0.0001; two-tailed unpaired t test. (C) qRT-PCR analysis of Angptl3 expression in the liver tissues of mice treated with or without AAV9-hAAT-Anc/Angptl3. ***p < 0.001; two-tailed unpaired t test. (D) Western blot analysis of ANGPTL3 in the mouse liver tissues treated with or without AAV9-hAAT-Anc/Angptl3 (60 µg per lane). GAPDH was probed as a loading control

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Cell & Bioscience

ISSN: 2045-3701

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