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Fig. 3 | Cell & Bioscience

Fig. 3

From: RRM2 silencing suppresses malignant phenotype and enhances radiosensitivity via activating cGAS/STING signaling pathway in lung adenocarcinoma

Fig. 3

RRM2 silencing inhibited cell migration and invasion. a The effects of RRM2 silencing on cell migration were evaluated with transwell assay in A549 and PC9 cells. Scale bar: 200 μm. b Quantification of the cell number of migrated cells. c The effects of RRM2 silencing on cell invasion were evaluated by Matrigel transwell assay. Scale bar: 200 μm. d Quantification of the numbers of cells crossing the Matrigel (invasion). e Immunoblotting of the EMT-related proteins. GAPDH was used as an internal control. f, g Relative intensity of key EMT-related proteins including E-cadherin and N-cadherin in A549 and PC9 cells after knockdown of RRM2. All tests were repeated 3 times. *p < 0.05, **p < 0.01, ***p < 0.001

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Cell & Bioscience

ISSN: 2045-3701

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