Skip to main content
Fig. 10 | Cell & Bioscience

Fig. 10

From: RRM2 silencing suppresses malignant phenotype and enhances radiosensitivity via activating cGAS/STING signaling pathway in lung adenocarcinoma

Fig. 10

The combination of RRM2 silencing and radiotherapy promotes the activation of cGAS/STING signaling pathway in LUAD cells. Knockdown RRM2 increases DNA damage accompanies by the increase of dsDNA in cytoplasm. Radiation also induces dsDNA accumulation in cytoplasm. The dsDNA fragments activate cGAS and then upregulate STING. Activated STING promotes the phosphorylation of IRF3. This triggers their translocation into the nucleus and results in the increased transcription and secretion of type I IFN genes, including IFNβ, CCL5 and CXCL10

Back to article page

Cell & Bioscience

ISSN: 2045-3701

Contact us