Table 1 Top 20 differential expressed genes/mRNAs in the p53-wt vs. p53-KO HBE cells post 12.5 µg/mL silica
Upregulated mRNA | Downregulated mRNA | ||||||
|---|---|---|---|---|---|---|---|
Gene-ID | Fold change | Log2 (Fold) | p value | Gene-ID | Fold change | Log2 (Fold) | p value |
ANKRD22 | 11.33825 | 3.503126 | 0.031888 | SLC9B1 | 0.062922 | − 3.99028 | 0.023555 |
GALNT16 | 5.9697 | 2.577658 | 0.015915 | GOLGA8Q | 0.067677 | − 3.88519 | 0.040364 |
LGR5 | 5.805771 | 2.537488 | 0.00641 | FAM19A5 | 0.068239 | − 3.87326 | 0.033308 |
ITGA9 | 5.201689 | 2.37898 | 0.033195 | LAIR2 | 0.07763 | − 3.68725 | 0.035158 |
ELMOD1 | 5.045316 | 2.334945 | 0.038847 | PLA2G2C | 0.182084 | − 2.45733 | 0.024876 |
GPT | 4.512969 | 2.174077 | 0.042918 | TNFRSF10C | 0.215358 | − 2.21519 | 0.018619 |
SCG3 | 4.258003 | 2.090177 | 0.028393 | NEU4 | 0.227828 | − 2.13399 | 0.040534 |
DEFA5 | 3.533064 | 1.82092 | 5.51E-05 | VAV1 | 0.325185 | − 1.62067 | 0.002011 |
DEFA6 | 3.417341 | 1.772874 | 0.002371 | SHC2 | 0.36299 | − 1.462 | 0.044092 |
CRYBB2 | 3.367854 | 1.751829 | 0.022507 | LOC107985524 | 0.384776 | − 1.37791 | 0.040135 |
JAKMIP2 | 3.267922 | 1.708373 | 0.022156 | DLX2 | 0.394143 | − 1.34321 | 0.022467 |
ZNF385B | 3.169598 | 1.6643 | 0.018243 | FNTB | 0.437081 | − 1.19403 | 0.039543 |
PRSS2 | 2.980291 | 1.575453 | 0.046668 | COL8A2 | 0.456718 | − 1.13063 | 0.006895 |
RNF103-CHMP3 | 2.964665 | 1.567869 | 0.00646 | PSG8 | 0.458618 | − 1.12464 | 0.015305 |
CHRNA1 | 2.764834 | 1.467193 | 0.009205 | SLC35F3 | 0.465274 | − 1.10385 | 0.041656 |
LRRC46 | 2.747 | 1.457857 | 0.04034 | AS3MT | 0.466297 | − 1.10068 | 0.006206 |
ADCY4 | 2.725217 | 1.446371 | 0.008368 | TREM2 | 0.47154 | − 1.08455 | 0.000655 |
LIX1 | 2.71129 | 1.438979 | 0.041953 | KCNMA1 | 0.479557 | − 1.06023 | 0.002141 |
KCND3 | 2.666753 | 1.415084 | 0.015511 | NANOS3 | 0.486488 | − 1.03952 | 0.046132 |
SLC24A3 | 2.665332 | 1.414315 | 0.033314 | SLC45A1 | 0.491734 | − 1.35907 | 0.008291 |