Fig. 1

Representative structure of Rab GTPases and schematic model of the role played by Golgi-associated Rab GTPases with established functions in autophagic pathways. a The typical structure of a Rab GTPase. SW: switch regions. HVD: hypervariable domain. C: C-terminal prenylation motif. GG: geranylgeranyl groups. b Golgi-associated Rab GTPase and their binding partners in autophagy. Rab1 and Rab6 have crucial roles in PAS formation; Rab33 and Rab37 are participated in Phagophore formation; Rab24 and Rab30 are involved in autophagosome formation; Rab9 and Rab11 mediate autophagosome-endosome fusion; Rab6 and Rab33 mediate autophagosome-lysosome fusion. PAS, pre-autophagosomal structure