Fig. 8
From: Structure, kinetic properties and biological function of mechanosensitive Piezo channels
Overview of the Piezo1/2 channel-regulated baroreceptor reflex. Both Piezo1 and Piezo2 channels were highly expressed in the nodose-petrosal-jugular-ganglion complex (NPJc), which contains the cell bodies of baroreceptor neurons. Shear stress from high blood pressure was transformed into an electronic signal through Piezo1/2 channel activation, which was relayed to the medullary cardiovascular center. Subsequently, the efferent impulse contacted its effector organs (heart and blood vessels), decreasing the subject’s blood pressure and heart rate