Pathophysiological roles and therapeutic potential of voltage-gated ion channels (VGICs) in pain associated with herpesvirus infection

Table 2 Summary of T-type Ca²⁺ channel distribution and the related channelopathy

Channel	Main distribution	Inflammatory pain	Neuropathic pain	Herpes virus-induced pain	Other related disease
Cav3.1	Excitatory neurons, inhibitory GABAergic neurons, TG and DRG	Decrease [140, 141]	Increase [138, 139]	N/A	Absence seizure, sleep/weak activity
Cav3.2	Small and medium diameter DRG	Increase [146]	Increase [147,148,149,150,151,152]	Decrease (lytic) [12, 18]	Cardiovascular disease, autism, hyperaldosteronism and seizure
Cav3.3	Small diameter neurons, smooth muscle cells	Increased [146]	Increase [147, 148]	N/A	Absence seizure

A report showed that HSV-1 infection has no regulatory effect on the expression of VGCC [10], but it did not indicate the regulatory effect of specific subtypes
N/A not applicable

ISSN: 2045-3701