From: Quercetin and cancer: new insights into its therapeutic effects on ovarian cancer cells
Type of quercetin | Mechanism(s) and effect(s) | Dose(s) | Model | Refs. |
---|---|---|---|---|
Graphene oxide polyvinylpyrrolidone-Quercetin-gefitinib (GO-PVP-QSR-GEF) | Cocktailed drug system GO-PVP-QSR-GEF has more cytotoxicity than individual and free drugs toward PA-1 ovarian cancer cells compared to IOSE-364 somatic ovarian epithelial cells | 10Â mg/l | In vitro | [98] |
Quercetin | Represses cell growth and induce apoptosis via reducing Bcl-2, Bcl-xL and increasing the expression level of caspase-3, caspase-9, cyto- c, Bid, Bad, and Bax in PA-1cell line | 75 μM | In vitro | [99] |
Quercetin | Regulate proliferation, apoptosis, and steroid and peptide hormone secretions in ovarian cells via decreasing PCNA and increasing BAX and in pigs cells T production and also IGF-I secreting reduced but in cattle cells, T releasing increased and at the lower concentration (1 or 10Â ng/mL) and a high concentration (100Â ng/mL), IGF-I releasing promoted and reduced, respectively | 1Â ng/mL, 10Â ng/mL, 100Â ng/mL | In vitro, in vivo | [139] |
Micellar(nanostructures) resveratrol (R): Quercetin (Q) (mRQ) | Alleviates the ADR-induced cardiotoxicity | 2.11Â mg/ml | In vitro, in vivo | [140] |
Quercetin | Regulates porcine ovarian granulosa cell roles in vitro via the pathway that may incorporate progesterone, cyclin B1 and p53 | 0.01 μmol/l, 0.1 μmol/l, 1 μmol/l, 10 μmol/l, 100 μmol/l | In vitro | [141] |
Quercetin | Intensify tumor radiosensitivity via p53-mediated ER stress pathways | 100 μmol/l | In vitro, in vivo | [102] |
Quercetin | Combination treatment of Q1 with xylene shows restricted the effect of xylene on proliferation and IGF-I release, provoked the instigator operation of xylene on apoptosis, and increased the impact of xylene on the release of progesterone but not testosterone | 1 μg/ml, 10 μg/ml, 100 μg/ml | In vitro | [20] |
Quercetin | Provokes protective autophagy and apoptosis via ER stress by the p-STAT3/Bcl-2 axis in ovarian cancer | 40 μM, 80 μM | In vitro, in vivo | [101] |
Quercetin | Leads to repression of proliferation and the initiation of apoptosis in ovarian cancer SKOV-3 cells; but, the precise mechanism still needs more investigation | 0.12Â mg/ml, 0.23Â mg/ml, 0.47Â mg/ml, 0.94Â mg/ml, 1.88Â mg/ml, 3.75Â mg/ml, 7.5Â mg/ml, 15Â mg/ml, 30Â mg/ml | In vitro | Â |