Category | NSAIDs | Usage and dosage | Function (longest time point, month) | Refs. |
---|---|---|---|---|
NSAIDs | NSAIDs | Daily use | No effect on bone resorption | [23] |
Regular and incidental use | No effect on bone remodeling | [88] | ||
5–7 times/week | Modest beneficial effect on BMD, no protective effect on subsequent risk of fractures | [87] | ||
COX-2 inhibitor | Celecoxib | 200–400 mg/day | Reduces radiographic progression of structural damage of ankylosing spondylitis (24 m) | [109] |
200Â mg/day | No effect on osteointegration of cementless total hip stems | [110] | ||
2 or 4Â mg/kg/day | Impairs fracture healing | [89] | ||
Acetic acid | Diclofenac | 150Â mg/day | Inhibits bone resorption | [111] |
Indomethacin | 75Â mg/day | No difference in fracture healing grade distribution | [112] | |
100Â mg/day | Impairs fracture healing grade | [101] | ||
Propionic acid | Flurbiprofen | 200Â mg/day | Decreases excellent functional result | [113] |
2400Â mg/day | Bone loss around implants (6Â m) | |||
1200Â mg/day | Increases bone resorption | [90] | ||
Naproxen | 1000Â mg/day | Bone defect fill and resorption (9Â m) | [114] | |
Flurbiprofen | 100Â mg/day | Inhibits periosteal bone formation Inhibits bone resorption | [115] | |
Enolic acid | Piroxicam | 20Â mg/day | No effect on BMD and fracture healing | [116] |