Cell | KIT genotype | Sensitivity to imatinib | IC50 (μM) | ||||
---|---|---|---|---|---|---|---|
HQP1351 | Ponatinib | Sunitinib | Regorafenib | Imatinib | |||
GIST T1 | exon 11, △560–578 | Sensitive | 0.027 ± 0.021 | 0.021 ± 0.000 | 0.015 ± 0.012 | 0.079 ± 0.046 | 0.027 ± 0.005 |
GIST 430 | exon 11, △560–576 | Resistant | 0.091 ± 0.021 | 0.134 ± 0.057 | 0.485 ± 0.168 | 3.321 ± 1.261 | 1.620 ± 0.318 |
exon13, V654A |