From: Radiation: a poly-traumatic hit leading to multi-organ injury
Function | Category | Major players |
---|---|---|
Vascular tone | Vasodilators | NO, PGI2 |
Vasoconstrictors | ET-1, Ang II, TXA2 | |
Coagulation | Anticoagulants | TM, TFPI, PGI2 |
Pro-coagulants | TF, PAR-1, TXA2 | |
Fibrinolysis | Anti-fibrinolytic | PAI-1 |
Pro-fibrinolytic | tPA | |
Leukocyte adhesion (inflammation) | Inflammatory mediators | IL-6, IL-8, MCP-1 |
Adhesion molecules | P-selectin, E-selectin, ICAM-1, PECAM-1, VCAM-1 | |
Platelet adhesion (thrombosis) | Â | VWF, fibrinogen |
Vascular permeability | Â | RAGE |
Vascular growth | Â | VEGF, PDGF, FGF, TGF-b |