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Table 5 Top ten altered canonical pathways, sorted by − log10 (p) value via IPA

From: Epigenetic alterations in TRAMP mice: epigenome DNA methylation profiling using MeDIP-seq

Pathways

− Log10 (p value)

Involved molecules

Neuropathic pain signaling in dorsal horn neurons

3.01

TACR1, GRM7, KCNN3, CAMK1D, MAPK1, GPR37, BDNF, GRM3, GRIA1, CREB1, TAC1, GRIN3A

Cardiomyocyte differentiation via BMP receptors

3.01

NKX2-5, MAP3K7, SMAD6, MEF2C, BMP10

cAMP-mediated signaling

2.75

ENPP6, ADCY2, RGS18, MAPK1, CAMK1D, PTGER3, GRM3, DUSP6, GNAI1, CHRM3, Cngb1, GRM7, FSHR, RGS10, CREB1, HTR1F, DRD3, PTGER4, PPP3CA

Estrogen biosynthesis

2.64

CYP4F8, CYP3A5, HSD17B7, CYP2C9, CYP2A6 (includes others), CYP51A1, CYP2C8

PXR/RXR activation

2.63

CYP3A5, ABCC2, INS, CYP2C9, CYP2A6 (includes others), INSR, PAPSS2, Ins1, CYP2C8

Wnt/β-catenin signaling

2.43

CDKN2A, GJA1, WNT3, APPL2, APC, SOX17, SOX2, FZD8, PPP2R1A, WNT7A, RARB, TLE4, MAP3K7, NR5A2, GSK3B

BMP signaling pathway

2.43

MAP2K4, NKX2-5, MAPK1, BMP8A, CREB1, MAP3K7, SMAD6, GREM1, BMP10

Factors promoting cardiogenesis in vertebrates

2.41

FZD8, SMAD2, NKX2-5, WNT3, BMP8A, MAP3K7, MEF2C, GSK3B, BMP10, APC

Glutamate receptor signaling

2.40

GRM7, SLC1A4, GRM3, GRIA1, SLC38A1, GRIP1, GRIK2, GRIN3A

Human embryonic stem cell pluripotency

2.39

SOX2, FZD8, SMAD2, WNT7A, WNT3, BDNF, BMP8A, SMAD6, GSK3B, NGF, APC, INHBA, BMP10

LPS/IL-1 mediated inhibition of RXR function

2.37

MAP2K4, GAL3ST2, ABCC2, CYP2C9, APOC2, NDST4, PAPSS2, IL1R2, TLR4, UST, CYP3A5, Sult1c2 (includes others), MAP3K7, NR5A2, CYP2A6 (includes others), GSTP1, MAOA, CYP2C8