Table 1 The role of DNA methylation in the pathogenesis of diabetic retinopathy
From: Diabetic retinopathy: reversibility of epigenetic modifications and new therapeutic targets
Refs | Study type | DNA methylation |
|---|---|---|
Diabetes Metab [9] | Clinical study (serum) | Global DNA methylation↑ |
BMC Med [10] | Clinical study (blood) | DNA methylation↓ in PDR, differential DNA methylation of 28 CpG sites in 17 genes (AHRR, GIPR, GLRA1, and BCOR) |
Invest Ophthalmol Vis Sci [11] | Invitro/animal (STZ diabetic mice) Retina | DNA methylation of polymerase gamma (POLG1) gene ↑ |
Lab Invest [13] Diabetes [12] | Invitro/animal (STZ diabetic mice) Retina | Dnmt1 binding to Matrix metalloproteinase -9 promoter→MMP↑→5mC↓ |
Invest Ophthalmol Vis Sci [14] | Invitro/animal study (Bovine retinal endothelial) | mtDNA methylation↑ |