Fig. 2

ImKTx88 protects the BBB in EAE rats. a Macroscopic images of whole brains and spinal cords (n = 6) on day 21 after EAE induction. Evans blue was injected into the tail vein 60 min before euthanization, and the brains, as well as the lumbar enlargements, were removed to detect Evans blue extravasation in the four groups. b Quantification of Evans blue dye extracted from homogenized samples. Data are representative of three independent experiments and represent the mean ± SEM, ***P < 0.001