Fig. 2

Effect of miR-338-5p expression on GCSC proliferation. Cell proliferation was assessed by the MTT assay in MKN45-derived (a, c) and MKN74-derived GCSCs (b, d) 24 h, 48 h, and 72 h after transfection with miR-338-5p mimic or inhibitor. The effect of miR-338-5p expression on GCSC viability was determined by an MTT assay. Viable cells were counted in MKN45 (c) and MKN74 GCSCs (d) 24 h, 48 h, and 72 h after transfection with miR-338-5p mimic or inhibitor (Filled circle represents the control, open circle represents the vehicle control, filled inverted traingle represents the mimic, open triangle represents the inhibitor). *(P < 0.05) and **(P < 0.01) represent comparisons of two symbols in the same row at a set time