Fig. 6From: Bioinformatic analysis reveals the expression of unique transcriptomic signatures in Zika virus infected human neural stem cellsActivation of NF-κB and STATs signaling pathway in ZIKV-infected hNPCs. Cytokines (IL-1 and TNF-α), PAMPs, CD40 and CXCL12 interact with their receptors resulting in activation of the NF-κB pathway. IFN-γ, IL-6 and IL-12 binding to their receptors induces STAT dimerization and translocation to the nucleus. Activation of both the canonical NF-κB and STAT signaling pathways, results in the production of numerous inflammatory cytokines.Back to article page