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Table 1 Breakpoints detected within the AF9 gene in H2O2-treated cells

From: Potential role of oxidative stress-induced apoptosis in mediating chromosomal rearrangements in nasopharyngeal carcinoma

Cell line treated with H2O2

Breakpoint

Remarks

HK1

245,590

This chromosomal break falls within the AF9 region (at coordinates 245252–245612) that translocates with the MLL gene, resulted in MLL-AF9 fusion gene previously identified in ALL patient [GenBank:AM050804]. This breakpoint is three nucleotides different from a breakpoint (at coordinate 245593) reported in cultured normal blood cells treated with VP16 [35]

245,677

 

245,823

 

245,850

 

245,892

 

246,110

This breakpoint is four nucleotides different from a breakpoint (at coordinate 246114) reported in CEM cells treated with VP16 [35]

NP69

245,580

This chromosomal break falls within the AF9 region (at coordinates 245252-245612) that translocates with the MLL gene, resulted in MLL-AF9 fusion gene previously identified in ALL patient [GenBank:AM050804]

245,591

This chromosomal break falls within the AF9 region (at coordinates 245252-245612) that translocates with the MLL gene, resulted in MLL-AF9 fusion gene previously identified in ALL patient [GenBank:AM050804]. This breakpoint is two nucleotides different from a breakpoint (at coordinate 245593) reported in cultured normal blood cells treated with VP16 [35]

245,613

This breakpoint is 1 nucleotide different from a breakpoint (at coordinate 245612) identified in ALL patient [GenBank:AM050804]

245,659

 

245,703

 

245,796

 

245,944

 

246,000

 

246,057

 

246,113

This breakpoint is one nucleotide different from a breakpoint (at coordinate 246114) reported in CEM cells treated with VP16 [35]

  1. The nucleotide positions of the chromosomal breaks detected within the AF9 gene were mapped according to the AF9 sequence accessed from Ensembl database [EMBL:ENSG00000171843]