Fig. 8

MTMR14 deficiency altered PI3K/AKT and ERK signaling pathways in fat, muscle and liver. a Expressions levels of Glut4 in fat. b, c The phosphorylation levels of ERK and AKT in fat of WT and MTMR14 KO mice at different ages (4, 18, and 34 weeks) were detected. d The expression levels of Glut4 in muscles of MTMR14 WT and KO mice. e, f The phosphorylation levels of ERK and AKT in muscles of WT and MTMR14 KO mice at different ages (4, 18, and 34 weeks) were detected. g The expression levels of Glut4 in the livers of MTMR14 WT and KO mice. h, i The phosphorylation levels of ERK and AKT in livers of WT and MTMR14 KO mice at different ages (4, 18, and 34 weeks) were detected. Quantitative measurements of Glut4, p-ERK, p-ARK proteins in fat, muscle and liver tissue of WT (blue) and KO (red) mice are shown underneath the original pictures. *p < 0.05, **p < 0.01, ***p < 0.001. β-actin was included as a control