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Fig. 5 | Cell & Bioscience

Fig. 5

From: Transient blocking of NK cell function with small molecule inhibitors for helper dependant adenoviral vector-mediated gene delivery

Fig. 5

Model depicting the interaction of gene transduced bronchial epithelial cells with NK cells and macrophages. Cascade of events leading to killing of gene transduced bronchial epithelial cells can be broken by transiently inhibiting NK cell activation at its peak response in HD-Ad gene therapy. Apart from protecting gene transduced cells from NK cell mediated killing, this inhibition will also help in dampening the induction of adoptive immune response

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