Figure 4From: Absence of Appl2 sensitizes endotoxin shock through activation of PI3K/Akt pathwayIncreased production of TNFα and IL-1β in Appl2 KO macrophages. (A) Kinetics of TNFα expression in the LPS-stimulated primary macrophages of the Appl2 KO and control mice. (B) Kinetics of IL-1β expression in the LPS-stimulated primary macrophages of the Appl2 KO and control mice. *p < 0.05, compared with WT mice, n = 5.Back to article page