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Figure 3 | Cell & Bioscience

Figure 3

From: Absence of Appl2 sensitizes endotoxin shock through activation of PI3K/Akt pathway

Figure 3

Appl2 KO mice are more prone to endotoxic shock than WT mice. (A) Kaplan-Meier survival curves of the WT (n = 9) and the Appl2 KO (n = 9) mice after LPS challenge (20 mg/kg weight, intraperitoneal injection). Compared with the WT mice, the Appl2 KO mice were more susceptible to the endotoxin challenge. (B) Photographs of the WT and Appl2 KO mice 24 h after intraperitoneal injection of LPS. WT mice showed only mild effects, whereas the Appl2 KO mice exhibited typical signs of endotoxemia. (C) HE-stained kidney sections from mice at 24 h post-LPS challenge. (D) Mouse serum TNFα level at 60 min after LPS injection. (E) Time course of the IL-1β expression in the LPS-stimulated Appl2 KO and control mice. Scale bar: 50 μm; *p < 0.05, compared with WT mice, n = 6.

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