Figure 3
From: The critical roles of COUP-TFII in tumor progression and metastasis
Potential model for COUP-TFII function in tip and stalk cell specification during angiogenesis. COUP-TFII is preferably expressed in tip cells to ensure the inactivation of Notch signaling and activation of VEGFR-2 signaling during the sprout process. In stalk cells, Notch signaling and VEGFR-1 expression will be up-regulated due to the absence of COUP-TFII.