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Table 3 Top differentially - expressed miRNAs with negative fold changes

From: Clinical biomarkers of pulmonary carcinoid tumors in never smokers via profiling miRNA and target mRNA

miRNA

Bonferroni P-value (FF sample set)

FDR (Q-value) (FF sample set)

Fold change (FF sample set)

Bonferroni P-value (FFPE sample set)

FDR(Q-value) (FFPE sample set)

Fold change (FFPE sample set)

miR-203

7.65E - 12

9.81E - 13

−5.27985

2.53E - 08

1.40E - 10

−3.47194

miR-224

3.35E - 09

4.77E - 11

−3.98143

6.67E - 07

3.26E - 09

−3.02567

miR-155

4.18E - 08

3.73E - 10

−3.79316

1.98E - 08

1.13E - 10

−3.00440

miR-302d

1

0.0280996

−2.07804

0.213123

0.000384031

−2.89387

miR-34b

6.04E - 05

2.53E - 07

−3.97282

0.0647553

0.000135572

−2.84861

miR-181b

6.15E - 11

4.54E - 12

−2.78165

2.56E - 10

2.06E - 12

−2.84466

miR-193a-5p

6.09E - 06

2.96E - 08

−2.47796

2.56E - 08

1.40E - 10

−2.82774

miR-34b*

0.202781

0.0003304

−2.35874

0.0239414

5.51E - 05

−2.68848

miR-222

6.14E - 09

7.38E - 11

−3.23244

0.0021736

6.33E - 06

−2.66284

miR-30a-3p

5.59E - 10

2.38E - 11

−3.68236

0.00758472

2.00E - 05

−2.65532

miR-938

1

0.032323

−2.11394

0.558499

0.000831352

−2.64146

miR-218

9.63E - 07

6.17E - 09

−3.60068

0.00014186

5.71E - 07

−2.54212

miR-511

6.18E - 10

2.38E - 11

−3.62032

2.35E - 05

1.01E - 07

−2.41325

miR-34c-3p

2.70E - 05

1.16E - 07

−3.12580

0.0165783

3.88E - 05

−2.37615

miR-10a

1.03E - 06

6.37E - 09

−3.11085

0.306927

0.000528712

−2.07425

miR-146a

5.81E - 06

2.87E - 08

−3.13742

0.0120827

2.95E - 05

−1.91491

miR-1

3.78E - 11

3.63E - 12

−3.16869

0.339905

0.000564228

−1.75322

  1. Note: We sorted miRNA on negative fold changes of FFPE and FF sample sets, respectively. We selected the top 12 in FF and FFPE of which the fold changes are denoted in italics, respectively. Seven miRNAs are the top 12 in both of the sample sets, and the other ten miRNAs are the top 12 in either of the sample sets. If the Bonferroni P-value or FDR (Q-value) are <0.05 or <0.01, they are labeled in bold font, respectively. Six miRNAs met all the criteria, i.e., Bonferroni P-value<0.05, FDR (Q-value)<0.01, and top fold changes in both sample sets are indicated by the deep shaded rows.
  2. FF=Fresh Frozen tissues.
  3. FFPE=Formalin-Fixed Paraffin-Embedded tissues.
  4. FDR=False Discovery Rate.
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Cell & Bioscience

ISSN: 2045-3701

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