Table 1 Summary of epigenetic factors that regulate CSCs
Name of gene | Protein function | Cancer type |
|---|---|---|
TET family (TET1, TET2, TET3) | DNA demethylases | Prostate cancer, breast cancer, liver cancer, lung cancer, leukemia, melanoma |
Dnmt1 | DNA methylase | Leukemia |
Ezh2 | H3K27me3 HMT | Leukemia, breast cancer, prostate cancer, pancreatic cancer, ovarian cancer |
Bmi1 | PRC1 component | Glioblastoma |
MLL1 | H3K4me3 HMT | Glioblastoma |
Lsd1 | H3K4/K9 demethylase | Teratocarcinoma, embryonic carcinoma, seminoma |