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Table 1 GABAergic cortical interneuron subtypes

From: Development and specification of GABAergic cortical interneurons

Marker

% Total GABA + Population

Morphology

Axonal targeting

Firing pattern

Origin

Parvalbumin (PV)

40

Basket cells

Proximal dendrites/soma

Fast-spiking

Ventral MGE

Chandelier cells

Axonal initial segment

Somatostatin (SST)

30

Martinotti cells

Distal dendrites

Bursting

Dorsal MGE

5HT3aR

30

VIP+: Small bipolar

Proximal dendrites

Irregular-spiking,

CGE

VIP-: Neurogliaform cells

Other GABA neurons

Fast-adapting

Late spiking accommodating

  1. Three markers account for nearly 100 percent of the GABAergic cortical interneuron population: parvalbumin (PV), somatostatin (SST), and 5HT3a receptor (5HT3aR). Outlined in this table are percentage of total GABA-expressing neurons, morphology, axonal targeting, firing pattern, and origin based on the type of marker expressed.