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Figure 1 | Cell & Bioscience

Figure 1

From: Development and specification of GABAergic cortical interneurons

Figure 1

Origin of GABAergic Cortical Interneurons. Anatomy of the embryonic telencephalon at approximately embryonic day 13.5 (E13.5), showing the major origins of GABAergic cortical interneurons. A Sagittal (top) view of the telencephalon. The MGE is labeled in pink and represents Lhx6- Nkx2.1-positive areas. MGE-derived interneurons ultimately express either PV or SST in the cerebral cortex. The CGE is labeled in light blue and represents Lhx6-positive, Nkx2.1-negative areas. CGE-derived interneurons ultimately express 5HT3aR in the cortex. The gray-labeled area represents Dlx1/Mash1-expressing areas. The black dotted line represents the migratory route interneuron precursors take to the cortex. B Coronal view of the telencephalon. Interneuronal progenitors originating in the LGE are labeled in blue; MGE-derived progenitors are labeled in green, and interneurons from the preoptic area are labeled in red. Abbreviations: CR, calretinin; CGE, caudal ganglionic eminence; IN, interneuron; LGE, lateral ganglionic eminence; MGE, medial ganglionic eminence; OB, olfactory bulb; PV, parvalbumin; POA, preoptic area; SST, somatostatin.

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