Figure 3

Some of the key players in asymmetric cell division of Drosophila neuroblasts. Asymmetric localization of proteins in dividing neuroblasts. Basal proteins are visualized in green, while apically localized proteins are visualized in blue. Apical proteins Bazooka, aPKC, and Par-6 form a complex whose responsibility is to establish cell polarity. There is a second complex of apical proteins, which consists of Gαi, Pins, and Loco. This complex is linked to Baz-aPKC-Par-6 by another protein known as Inscuteable. Aurora-A phosphorylates Par-6 to control aPKC’s substrate specificity. The proteins Miranda, Brat and Prospero form a complex that is basally located. PON and Numb are two other basal proteins that form a separate complex; both complexes work to regulate differentiation of the GMC.