Nuclear hormone receptors in podocytes

Cell & Bioscience

Table 2 A summary of the physiological function of nuclear hormone receptors in podocytes

Nuclear receptor	Role in kidney function/disease	Reference
Estrogen receptor	renoprotective blocks podocyte apoptosis	[61–64]
Glucocorticoid receptor	well-known renoprotective functions of GR ligands	[56, 65–67]
Mineralocorticoid receptor	renoprotective when suppressed	[68–74]
Peroxisome proliferator-activated receptor-α	renoprotective enhances Nephrin expression	[75–78]
Peroxisome proliferator-activated receptor-γ	renoprotective blocks podocyte apoptosis blocks podocyte hypertrophy/proliferation	[79–82]
Retinoic acid receptor-α	renoprotective enhances podocyte differentiation	[83–90]
Vitamin D receptor	reduces renal inflammation enhances Nephrin expression	[91–95]

ISSN: 2045-3701