Figure 1From: Roles of TGFβ signaling Smads in squamous cell carcinomaSchematic of Smads mediated TGFβ signaling pathway. TGFβ ligand binds to TGFβRII/TGFβRI receptors leading to phosphorylation of Smad2/3. Phosphorylated Smad2/3 binds to Smad4 to form a protein complex that undergoes nuclear translocation and regulates the expression of TGFβ target genes through binding to the Smad-binding element (SBE).Back to article page