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Table 1 miRNAs regulated by NRs

From: Regulation of microRNA expression and function by nuclear receptor signaling

miRNA name

Regulation

note

target

Ref.

Let 7 family

ER;PPAR;PR

induced by estradiol; PPARα and PR agonist regulate let-7c.

K-ras; HMGA2; caspase-3; c-Myc; PGRMC1

[28, 51, 57, 88–94]

miR-17-92

cluster

ER

c-Myc, adiol, binds induced by estr to the miR-

17-92 promoter; p53 and STAT3 bind to the miR-17-92 promoter.

Myc;E2F;HNF1;PTEN;B

IM;ER;AIB1;cyclin D1

[30, 88, 95, 96]

miR-21

ER;AR

STAT3, NF-κB, CREB and CBP/p300, ER and AR bind to the miR-21 promoter.

Pdcd4;PTEN;PPARα;

[28, 97–101]

miR-221/222

ER;AR

NF-κB, c-JUN, ER and AR bind to the miR-221/222 promoter.

P27kip1;PTEN;ERα;PUM A

[29, 45, 102–106]

miR-200 family

ER;AR;PR

upregulated by estradiol, androgen and progesterone.

ZEB1; ZEB2; BMI1

[38, 50, 107]

miR-146a

ER;AR

repressed by estradiol, androgen and LPS; LPS induces NF-κB binding to the miR-416a promoter.

ROCK1; TRAF6; IRAK1; BRCA1; CD40L; STAT1

[39, 108–112]

miR-26a

ER;AR

Estradiol induces miR-26a, which reduces PR mRNA level

EZH2;MTDH

[113, 114]

miR-101

AR

ARE identified in the miR-101 promoter

EZH2; MAGI-2; MKP-1;

ATP5B; COX-2; MYCN

[41, 115–120]

miR-125b

AR

AR loading to the 5' UTR region

MUC1; PIGF; IGF-II; FGFR2; P53;PUMA;E2F3

[121–126]

miR-122

HNF4α

HNF4α binds to the miR-122 promoter.

Hfe; Hjv; CPEB; HCV;

CAT-1; Smarcd1/Baf60α

[55, 127–131]

miR-29a

FXR

FXR-responsive element in the miR-29a promoter; regulated by TGF-β, c-Myc, Hedgehog or NF-κ B

Ski; MCT1; PTEN; CDK6

[62, 63, 132–135]

miR-210

RARα/RXRα

RARα/RXRα heterodimers bind to the miR-210 promoter

FGFRL1; HOXA3; E2F3; RAD52

[70, 136–138]

miR-23a/24-2

RARα/RXRα

RARα/RXRα heterodimers bind to the miR-23a/24-2 promoter

Runx2; XIAP; IL6R

[70, 139–141]

miR-9

TLX

TLX binds to the downstream of miR-9 and miR-9 targets TLX mRNA to form a feedback loop

PDGFR-β; Nr2e1; FoxP1; Gsh2; NFκB1

[72, 142–145]

miR-34a

FXR;SHP

p53 binds to the miR-34a promoter; FXR interacts with p53 through SHP to regulate miR-34a

FoxP1; Bcl-2;CDK4;E2F3;

N-MYC;SIRT1;HMGA2

[59, 146, 147]

miR-433/127

SHP

SHP inhibits ERRγ which binds to the miR-433/127 promoters

HDAC6;BCL6

[80, 148, 149]

miR-206

SHP

SHP represses ERRγ leading to decreased YY1 which inhibits AP1 activation of the miR-206 promoter

Notch3; HDAC4; KLF4; Pax7

[81, 82, 150–153]