From: Regulation of microRNA expression and function by nuclear receptor signaling
miRNA name | Regulation | note | target | Ref. |
---|---|---|---|---|
Let 7 family | ER;PPAR;PR | induced by estradiol; PPARα and PR agonist regulate let-7c. | K-ras; HMGA2; caspase-3; c-Myc; PGRMC1 | |
miR-17-92 cluster | ER | c-Myc, adiol, binds induced by estr to the miR- 17-92 promoter; p53 and STAT3 bind to the miR-17-92 promoter. | Myc;E2F;HNF1;PTEN;B IM;ER;AIB1;cyclin D1 | |
miR-21 | ER;AR | STAT3, NF-κB, CREB and CBP/p300, ER and AR bind to the miR-21 promoter. | Pdcd4;PTEN;PPARα; | |
miR-221/222 | ER;AR | NF-κB, c-JUN, ER and AR bind to the miR-221/222 promoter. | P27kip1;PTEN;ERα;PUM A | |
miR-200 family | ER;AR;PR | upregulated by estradiol, androgen and progesterone. | ZEB1; ZEB2; BMI1 | |
miR-146a | ER;AR | repressed by estradiol, androgen and LPS; LPS induces NF-κB binding to the miR-416a promoter. | ROCK1; TRAF6; IRAK1; BRCA1; CD40L; STAT1 | |
miR-26a | ER;AR | Estradiol induces miR-26a, which reduces PR mRNA level | EZH2;MTDH | |
miR-101 | AR | ARE identified in the miR-101 promoter | EZH2; MAGI-2; MKP-1; ATP5B; COX-2; MYCN | |
miR-125b | AR | AR loading to the 5' UTR region | MUC1; PIGF; IGF-II; FGFR2; P53;PUMA;E2F3 | |
miR-122 | HNF4α | HNF4α binds to the miR-122 promoter. | Hfe; Hjv; CPEB; HCV; CAT-1; Smarcd1/Baf60α | |
miR-29a | FXR | FXR-responsive element in the miR-29a promoter; regulated by TGF-β, c-Myc, Hedgehog or NF-κ B | Ski; MCT1; PTEN; CDK6 | |
miR-210 | RARα/RXRα | RARα/RXRα heterodimers bind to the miR-210 promoter | FGFRL1; HOXA3; E2F3; RAD52 | |
miR-23a/24-2 | RARα/RXRα | RARα/RXRα heterodimers bind to the miR-23a/24-2 promoter | Runx2; XIAP; IL6R | |
miR-9 | TLX | TLX binds to the downstream of miR-9 and miR-9 targets TLX mRNA to form a feedback loop | PDGFR-β; Nr2e1; FoxP1; Gsh2; NFκB1 | |
miR-34a | FXR;SHP | p53 binds to the miR-34a promoter; FXR interacts with p53 through SHP to regulate miR-34a | FoxP1; Bcl-2;CDK4;E2F3; N-MYC;SIRT1;HMGA2 | |
miR-433/127 | SHP | SHP inhibits ERRγ which binds to the miR-433/127 promoters | HDAC6;BCL6 | |
miR-206 | SHP | SHP represses ERRγ leading to decreased YY1 which inhibits AP1 activation of the miR-206 promoter | Notch3; HDAC4; KLF4; Pax7 |