Table 3 CDSs related to multidrug resistance in L. hongkongensis
CDS | Gene | Product | Organism with the closest matching sequence | E-value | Identities | No. of TMSa | Remarksb |
|---|---|---|---|---|---|---|---|
LHK_00138 | tolC | TolC family type I secretion outer membrane protein | Polaromonas naphthalenivorans | 2e-72 | 203/455 (44%) | -- | OMP |
LHK_00140 | acrB | Acriflavin resistance protein | P. naphthalenivorans | 0 | 723/1066 (67%) | 13 | RND |
LHK_00141 | acrA | Efflux transporter, RND family, MFP subunit | P. naphthalenivorans | 2e-51 | 153/355 (43%) | -- | MFP |
LHK_00142 | arsR | Transcription regulator ArsR | Bordetella parapertussis | 2e-26 | 62/99 (62%) | -- | TR |
LHK_00221 | Â | RND efflux system outer membrane lipoprotein | Pelobacter propionicus | 1e-108 | 207/424 (48%) | -- | OMP |
LHK_00222 | macB | Macrolide-specific ABC-type efflux carrier | Bordetella avium | 0 | 429/655 (65%) | 4 | ABC |
LHK_00223 | macA | Efflux transporter, RND family, MFP subunit | Lutiella nitroferrum | 4e-127 | 252/384 (65%) | -- | MFP |
LHK_00466 | Â | Hypothetical protein | Dorea longicatena | 6e-45 | 131/439 (29%) | 12 | MATE |
LHK_00743 | mdfA | Probable multidrug translocase protein | C. violaceum | e-139 | 253/394 (64%) | 12 | MFS |
LHK_01214 | Â | Probable multiple antibiotic resistance protein MarC | C. violaceum | 7e-58 | 118/208 (56%) | -- | MarC |
LHK_01285 | mdtA | Probable membrane protein | C. violaceum | 3e-94 | 188/340 (55%) | -- | MFP |
LHK_01286_01287 | mdtB | Drug efflux pump transmembrane protein | C. violaceum | 0 | 700/1018 (68%) | 12 | RND |
LHK_01288 | mdtC | Drug efflux pump transmembrane protein | C. violaceum | 0 | 678/994 (68%) | 10 | RND |
LHK_01289 | tolC | Putative outer membrane protein precursor | Acinetobacter sp. | 4e-79 | 189/433 (43%) | -- | OMP |
LHK_01373 | emrB | Multidrug resistance protein | C. violaceum | 0 | 323/490 (65%) | 14 | MFS |
LHK_01374 | emrA | Multidrug efflux membrane fusion protein | Ralstonia eutropha | e-101 | 194/370 (52%) | -- | MFP |
LHK_01375 | mdtP | Outer membrane efflux protein | Yersinia enterocolitica | 1e-38 | 142/469 (30%) | -- | OMP |
LHK_01376 | emrR | MarR family transcriptional regulator | C. violaceum | 4e-32 | 69/156 (44%) | -- | TR |
LHK_01383 | Â | Probable multiple antibiotic resistance protein MarC | C. violaceum | 4e-80 | 149/232 (64%) | -- | MarC |
LHK_01384 | mdtJ | Multidrug efflux system protein MdtJ | Klebsiella pneumoniae | 3e-20 | 52/119 (43%) | 3 | SMR |
LHK_01385 | mdtI | Multidrug efflux system protein MdtI | Salmonella enterica | 6e-21 | 63/109 (57%) | 4 | SMR |
LHK_01424 | Â | RND efflux system, outer membrane lipoprotein, NodT family | Syntrophobacter fumaroxidans | 7e-108 | 223/446 (50%) | -- | OMP |
LHK_01425 | Â | Transporter, hydrophobe/amphiphile efflux-1 (HAE1) family | Pelobacter propionicus | 0 | 553/1036 (53%) | 12 | RND |
LHK_01426 | Â | Efflux transporter, RND family, MFP subunit | S. fumaroxidans | 7e-95 | 186/364 (51%) | -- | MFP |
LHK_01870 | Â | Putative multidrug resistance protein | R. eutropha | 8e-47 | 153/483 (31%) | 14 | MFS |
LHK_01934 | Â | Probable multiple antibiotic resistance protein MarC | C. violaceum | 3e-80 | 152/205 (74%) | -- | MarC |
LHK_01967 | Â | ABC transporter, transmembrane region:ABC transporter related | R. eutropha | 0 | 550/732 (75%) | 6 | ABC |
LHK_02051 | Â | Lipoprotein releasing system, ATP-binding protein | Pseudomonas stutzeri | 4e-58 | 134/227 (59%) | -- | ABC |
LHK_02129 | mexA | Multidrug resistance protein | Xanthomonas campestris | 3e-104 | 223/375 (59%) | -- | MFP |
LHK_02130 | acrB | AcrB/AcrD/AcrF family protein | Cellvibrio japonicus | 0 | 768/1034 (74%) | 14 | RND |
LHK_02131 | nodT | RND efflux system, outer membrane lipoprotein, NodT | Geobacter metallireducens | 8e-142 | 266/466 (57%) | -- | OMP |
LHK_02132 | Â | Transcriptional regulator, TetR/AcrR family | Cellvibrio japonicus | 2e-46 | 93/187 (49%) | -- | TR |
LHK_02173 | Â | Probable MFS transporter | C. violaceum | 1e-82 | 195/370 (52%) | 12 | MFS |
LHK_02235 | Â | Putative integral membrane efflux protein | Yersinia pestis | 0 | 379/505 (75%) | 13 | abgT family protein |
LHK_02238 | Â | ABC transporter | Azoarcus sp. | e-157 | 281/371 (75%) | 7 | ABC |
LHK_02239 | yhiH | ABC transporter related | Thauera sp. | 0 | 699/954 (73%) | 6 | ABC |
LHK_02240 | Â | Conserved hypothetical protein, predicted secretion protein HlyD family | Azoarcus sp. | 6e-96 | 232/339 (68%) | -- | MFP |
LHK_02241 | oprM3 | Outer membrane efflux protein | B. avium | 1e-100 | 241/453 (53%) | -- | OMP |
LHK_02292 | Â | Probable multiple antibiotic resistance protein MarC | C. violaceum | 2e-60 | 116/218 (53%) | -- | MarC |
LHK_02533 | Â | Multidrug efflux protein NorA | C. violaceum | e-122 | 230/447 (51%) | 12 | MATE |
LHK_02539 | Â | EmrB/QacA family drug resistance transporter | P. stutzeri | 2e-147 | 277/481 (57%) | 13 | MFS |
LHK_02783 | Â | Hypothetical protein multiple antibiotic resistance (MarC)-related protein | C. violaceum | 5e-74 | 139/200 (69%) | -- | MarC |
LHK_02825 | natC | Periplasmic type I secretion system | C. violaceum | 4e-82 | 190/439 (43%) | -- | OMP |
LHK_02826 | acrB | Probable transmembrane drug efflux protein | C. violaceum | 0 | 693/1019 (68%) | 12 | RND |
LHK_02827 | acrA | Probable transport/efflux transmembrane protein | C. violaceum | 3e-83 | 174/351 (49%) | -- | MFP |
LHK_02828 | acrR | TetR/AcrR family transcriptional regulator | C. violaceum | 6e-44 | 92/183 (50%) | -- | TR |
LHK_02929 | acrA | Probable multidrug efflux membrane permease | C. violaceum | 1e-89 | 203/372 (54%) | -- | MFP |
LHK_02930 | acrD | Acriflavin resistance protein D | C. violaceum | 0 | 717/1036 (69%) | 12 | RND |
LHK_02931 | oprM | Outer membrane efflux protein | C. violaceum | e-136 | 252/467 (53%) | -- | OMP |
LHK_02949 | msbA | Transport ATP-binding protein MsbA | C. violaceum | 0 | 344/554 (62%) | 5 | ABC |
LHK_02975 | bcr | Probable MFS transporter | C. violaceum | e-147 | 269/388 (69%) | 12 | MFS |
LHK_03132 | emrB | Probable multidrug resistance protein | C. violaceum | 0 | 303/492 (61%) | 14 | MFS |
LHK_03133 | emrA | Multidrug resistance protein | Burkholderia thailandensis | 1e-108 | 202/377 (53%) | -- | MFP |
LHK_03134 | tolC | Outer membrane efflux protein | R. eutropha | 6e-45 | 153/453 (33%) | -- | OMP |